[1PS-057]
우수논문발표상 응모자Supramolecular Biohybrid Nanocomplexes of Peptide Biomacromolecules for Oral Delivery of Semaglutide
발표자마가은 (건국대학교)
연구책임자박주호 (건국대학교)
Abstract
Peptide therapeutics represent an important class of biomacromolecular drugs, yet their clinical application remains limited by poor oral bioavailability. Here, we report a supramolecular biohybrid nanocomplex for oral delivery of the peptide drug semaglutide, where the peptide itself functions as a polymeric therapeutic component. A positively charged bile acid–peptide conjugate forms a reversible non-covalent assembly with semaglutide, enabling transporter-mediated endocytosis via ASBT while preserving peptide integrity under gastrointestinal conditions. This study highlights how biomacromolecular peptides can be engineered through supramolecular interactions, offering a bio-convergent strategy that connects peptide-based polymers with next-generation drug delivery technologies.