대학원생 구두발표(토론II): 의료용 고분자 과학과 미래 헬스케어
[OD2-2]
우수논문발표상 응모자Choline-Based Nanoparticles for Blocking Choline Transporter and Suppressing Tumor Growth
발표자박내학 (가톨릭대학교 약학대학)
연구책임자강한창 (가톨릭대학교 약학대학)
Abstract
Choline is an essential bioactive molecule that controls cell proliferation and homeostasis, acting as a precursor for phosphatidylcholine and betaine. Cancer cells require more choline, leading to increased expression of choline transporters to support their rapid growth. This study introduces a strategy to block these transporters with choline-decorated nanoparticles (CholPCL-NPs). Inhibiting choline uptake decreases phospholipid and betaine production, halting proliferation and DNA methylation, destabilizing epigenetic regulation, and ultimately causing cancer cell death. Additionally, doxorubicin-loaded nanoparticles (DOX@CholPCL-NPs) work together to kill cancer cells more effectively and inhibit tumor growth. Therefore, these results indicate that CholPCL-NPs are a promising nanomedicine platform for targeted cancer treatment.