The Polymer Society of Korea

Abstract

Bioactive hydrogels are promising biomaterials for tissue regeneration. Recently, the incorporation of exosomes has garnered attention for enhancing therapeutic efficacy and tissue repair. While animal-derived exosomes are prevalent, they have limitations such as high immunogenicity and significant costs. Conversely, plant-derived exosomes offer low immunogenicity and cost-effectiveness. Here, we developed perilla leaf-derived exosome-releasing hydrogels (Perex-Gels) via thiol-ene, amine-ene reactions, and disulfide bonds. Our hydrogels formed a network within 15-17 seconds and provided adequate mechanical strength (155-305 Pa) for stability in vivo. Additionally, Perex-Gels demonstrated a sustained release of Perex over 24 hours, both in vitro and in vivo. Notably, Perex-Gels accelerated wound healing by modulating M2 macrophage polarization and promoting angiogenesis in vivo. Overall, Perex-Gels exhibit significant potential as innovative bioactive materials for tissue regeneration