[3PS-266]
Nanoparticle-assisted surface patterning of microneedles for mechanical interlocking-based tissue adhesion
발표자장상수 (부산대학교)
연구책임자양승윤 (부산대학교)
Abstract
Nanopatterned microneedles (MNs) have garnered attention for modulating surface characteristics in drug delivery and biosensing applications. However, achieving precise nanopatterning on 3D polymeric MNs while maintaining structural stability remains a challenge. We report a method for fabricating 3D nanopatterns on MN surfaces using directionally controlled plasma etching. Gold nanoparticle-encapsulated micelles, anchored via electrostatic layer-by-layer deposition, served as etch masks for complex geometries. The resulting nanopatterns modified surface topography without compromising mechanical properties. Insertion force into porcine skin remained comparable to non-patterned MNs, indicating preserved functional integrity. Furthermore, nanopatterned MNs exhibited a six-fold increase in tissue adhesion compared to controls due to increased contact interfaces. This precise 3D nanopatterning strategy effectively tailors surface properties, offering broad applicability in biomedical engineering.