[2PS-057]
우수논문발표상 응모자Multifunctional GQD-PDRN Nanocomposite-Loaded Hyaluronic Acid for Integrated Tissue Regeneration and NIR-responsive Photothermal Therapy in Diabetic Wound Healing
발표자조윤하 (가톨릭대학교)
연구책임자강민호 (가톨릭대학교)
Abstract
Diabetic wounds are difficult to heal due to oxidative stress, infection, and impaired angiogenesis. To address these challenges, we developed a multifunctional hyaluronic acid (HA) hydrogel co-loaded with graphene quantum dots (GQDs) and polydeoxyribonucleotide (PDRN). GQDs, synthesized via a microwave-assisted method, exhibited strong reactive oxygen species (ROS) scavenging and near-infrared (NIR)-responsive photothermal properties. PDRN, known for stimulating tissue regeneration and angiogenesis, was embedded within the HA matrix. Upon NIR irradiation, GQD-mediated heating softened the hydrogel, enabling on-demand PDRN release and mild photothermal stimulation. This system enhanced fibroblast proliferation, supported angiogenesis, and accelerated diabetic wound healing in vitro with low cytotoxicity. These results suggest that the GQD-PDRN/HA hydrogel is a promising dressing platform integrating antioxidant, regenerative, and photothermal functions for diabetic wound treatment.