[2PS-056]
우수논문발표상 응모자Development of pH-Responsive Nanomedicine Based on Metal-Phenolic Networks for Targeted Drug Delivery
발표자조윤성 (국립한국교통대학교)
연구책임자신정민 (국립한국교통대학교)
Abstract
Although drug-loaded nanoparticles (NPs) hold promise for cancer therapy, premature drug leakage remains a significant clinical hurdle. To address this, we engineered pH-responsive nanocarriers by applying a metal-phenolic network (MPN) coating onto amphiphilic hyaluronic acid (HA) and PEG-PLGA NPs. Doxorubicin (DOX) and macitentan (a endothelin-1 receptor antagonist) were encapsulated in the HA and PEG-PLGA cores, respectively, with a tannic acid FeCl3 MPN shell acting as a diffusion barrier. The MPN coating remained intact at physiological pH but dissociated under acidic conditions, enabling tumor-specific drug release. While both NP types demonstrated successful MPN integration and stimuli-responsive behavior, HA NPs were selected for further evaluation. In vitro assays revealed that DOX-loaded MPN-NPs significantly improved anticancer efficacy compared to their uncoated counterparts. This gatekeeping strategy provides a robust framework for enhancing the precision of chemotherapy.