[3PS-079]
Liposome-Encapsulated Ferroptosis Inducers for Overcoming Cancer Metastasis and Drug Resistance
발표자류수현 (서울대학교)
연구책임자이강원 (서울대학교)
Abstract
Cancer metastasis and drug resistance are driven by metabolic reprogramming and extracellular matrix remodeling that also limit ferroptosis sensitivity. Here, we develop a liposomal nanoplatform coencapsulating iron oxide nanoparticles, lactate oxidase, and the lysyl oxidase inhibitor PAT-1251 to induce ferroptosis while suppressing metastasis-associated pathways. This system simultaneously promotes iron-dependent lipid peroxidation, depletes lactate, and inhibits LOX-mediated ECM remodeling. As a result, the platform enhances ferroptotic cell death, improves drug penetration, and reduces metastatic potential. In vitro and in vivo studies demonstrate effective tumor suppression and mitigation of drug resistance compared with single-component treatments. This work highlights a metabolism- and microenvironment-targeted ferroptosis strategy for advanced cancer therapy.