[1PS-060]
우수논문발표상 응모자Synergistic Strategies for Enhanced β-Cell Survival within Macroencapsulation Devices
발표자박민지 (인천대학교)
연구책임자양기석 (인천대학교)
Abstract
β-cell macroencapsulation is a promising therapy for type 1 diabetes (T1D) but faces challenges from immune-mediated fibrosis and hypoxia. This study presents a dual-strategy macroencapsulation device (MED) to address these issues. We applied an anti-inflammatory coating to poly(tetrafluoroethylene) (PTFE) membranes using initiated chemical vapor deposition (iCVD) and incorporated a novel oxygen-generating catalytic complex within the capsule. This synergistic approach significantly reduced fibrosis by promoting M2 macrophage polarization and effectively alleviated hypoxia, thereby enhancing β-cell viability and function. In a streptozotocin-induced diabetic mouse model, the functionalized MED demonstrated superior glycemic control for 45 days compared to controls. These results suggest that combining anti-inflammatory surface modification with oxygen-generating strategies effectively improves the longevity and therapeutic efficacy of β-cell encapsulation.