[3PS-144]
Second-Scale Room-Temperature Phosphorescent Silica Nanoparticles with in situ Generated Carbonaceous Defects for Theragnostic Applications
발표자이규림 (포항공과대학교)
연구책임자한세광 (포항공과대학교)
Abstract
Room-temperature phosphorescence (RTP) offers significant advantages for bioimaging due to its long emission lifetime and high signal-to-noise ratio under time-gated conditions. Here, we report silica nanoparticles with in situ–formed carbonaceous defects (CD@SNPs) that exhibit second-scale RTP. Crosslinked SNPs were synthesized via polycondensation of tetraethyl orthosilicate and (3-aminopropyl)triethoxysilane, generating a porous silica matrix. Calcination induced the formation of carbonaceous defects within the pores, whose molecular motion was effectively restricted by the rigid silica framework, enabling stable triplet-state emission and suppressed nonradiative decay. Furthermore, hyaluronic acid–coated SNPs (HA-SNPs) were developed for targeted cell imaging and drug delivery through HA–receptor–mediated interactions. The HA-SNPs can encapsulate anticancer drugs such as doxorubicin and provide simultaneous green RTP for real-time imaging.