[1PS-070]
우수논문발표상 응모자Mechanically Robust Biodegradable Stents with Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering
발표자서종화 (한양대학교)
연구책임자정현도 (한양대학교)
Abstract
Peripheral artery disease (PAD), characterized by occlusion of peripheral arteries, causes ischemic complications and limb dysfunction. Endovascular stenting remains a primary therapy; however, developing biodegradable vascular stents with mechanical resilience and antithrombotic surfaces remains challenging. This study presents a 3D-printed biodegradable drug-eluting stent using silica–polycaprolactone nanocomposites and Janus surface nanoengineering. Sol–gel-derived silica creates stents with tuned radial strength and elliptical struts reducing flow disturbance. Janus nanoengineering through tantalum plasma immersion creates a nano-Ta-enriched luminal surface promoting endothelial cell growth, while the abluminal layer with sirolimus/poly-L-lactic acid suppresses smooth muscle cell proliferation. In vitro and in vivo tests show improved patency, reduced neointimal hyperplasia, and favorable tissue responses, representing a promising platform for vascular engineering.