[3PS-088]
Sundew-Inspired 4D Platform for Minimally Invasive Bone Cancer Therapy and Bioadhesive Bone Regeneration
발표자서종화 (한양대학교)
연구책임자정현도 (한양대학교)
Abstract
Osteosarcoma remains difficult to treat due to recurrence, irregular bone defects, and insufficient vascularization, creating a need for multifunctional scaffolds that integrate therapy and regeneration. A bioinspired theragenerative platform was developed using 4D-printed shape memory polymer(SMP) scaffolds with synthetic adhesive-DNA(aDNA) immobilization. Inspired by sundew, the system embodies three levels of mimicry: motion mimicry through NIR-triggered shape recovery enabling minimally invasive implantation, surface mimicry via aDNA immobilization providing stable adhesion, and functional mimicry through aDNA-derived bioactivities with therapeutic reactions by near-infrared (NIR) irradiation. aDNA immobilization enhanced osteogenic differentiation, angiogenic activity, antioxidative effects, and immunomodulation. Under NIR irradiation, thermal modulation enabled tissue regeneration and tumor ablation with high density as a multifunctional theragenerative platform.