[O9-2]
우수논문발표상 응모자Surface Immobilization of Parabens on UV Filter Nanoparticles to Prevent Skin Absorption of Parabens
발표자이양우 (서울과학기술대학교)
연구책임자구형준 (서울과학기술대학교)
Abstract
Parabens are common preservatives in cosmetics, but raise safety concerns due to skin absorption and potential hormonal effects. This study introduces a method to immobilize parabens onto TiO₂ nanoparticles to block skin penetration while retaining their antimicrobial property. We employed linker molecules to facilitate stable binding between parabens and TiO₂. Surface modification was confirmed via zeta potential and FTIR, with TGA quantifying linker loading. HPLC analysis demonstrated a 160% increase in paraben adsorption on functionalized particles compared to pristine TiO₂. In vitro assays using human dermal fibroblasts showed conformal cytotoxicity for the paraben-immobilized particles. Furthermore, enhanced antibacterial activity against Staphylococcus aureus is achieved. These findings suggest that anchoring parabens to TiO₂ nanoparticles offers a promising route for effective preservation with reduced dermal absorption risks of parabens.