대학원생 구두발표(토론II): 의료용 고분자 과학과 미래 헬스케어
[OD2-3]
우수논문발표상 응모자A Multifunctional Lipid–Polymer Platform for Natural Killer Cell Surface Engineering in Glioblastoma Immunotherapy
발표자유민선 (동국대학교)
연구책임자김교범 (동국대학교, Cellbastian)
Abstract
Glioblastoma (GBM) remains highly lethal despite aggresive therapies, prompting interest in natural killer (NK) cell-based immunotherapy. However, efficient blood-brain barrier (BBB) delivery and GBM specificity remain key challenges for clinical translation. To address these limitations, we introduced a lipid-based polymer incorporating hyaluronic acid (HA) and glucosamine (Glc) onto NK cell surfaces via hydrophobic interactions through a simple 30-min incubatioin. This modification enabled outward presentation of Glc (a GLUT1 ligand) and HA (a CD44 ligand), enhancing interactions with GLUT1-overexpressing BBB endothelial cells and CD44/GLUT1-overexpressing GBM cells. As a result, surface-engineered NK cells efficiently transmigrated the BBB and selectively recognized GBM cells, leading to synergistic tumor elimination in an orthotopic GBM mouse model. Collectively, this study introduces a simple, non-genetic NK cell engineering strategy for clinically translatable GBM immunotherapy.