The Polymer Society of Korea

Abstract

Chronic wounds in diabetic patients are difficult to treat due to persistent inflammation, impaired angiogenesis, and oxidative stress. To address this, we developed injectable DNA-guided siliceous microgels inspired by marine biosilica and refined through AI-based modeling for tunable particle sizes ensuring syringe compatibility. These microgels showed robust structural integrity, biomimetic features, and colloidal stability. Silica-infused formulations exhibited excellent biocompatibility, exudate absorption, ROS scavenging, and hemostatic performance. In vitro, they promoted M2 macrophage polarization, fibroblast/endothelial cell proliferation, and oxidative protection. In vivo, they accelerated wound closure, re-epithelialization, collagen deposition, and angiogenesis while reducing inflammation. This platform supports all wound healing phases, offering a multifunctional strategy for chronic wound therapy.