대학원생 구두발표(토론II): 의료용 고분자 과학과 미래 헬스케어
[OD2-11]
우수논문발표상 응모자A large puncture closer of aortic wall by multi-memory actions with thrombo-hemodynamic control
발표자조성우 (연세대학교)
연구책임자성학준 (연세대학교)
Abstract
Vascular wall regulates blood flow and pressure, making secure closure of vascular punctures essential in cardiovascular interventions. However, large punctures (>6 mm) under severe bleeding remain difficult to hemostasis and manage and are highly operator-dependent. Here, we present a shape memory vascular wall plug (VWP) that enables autonomous hemostasis through multi-actions of Body, Wing, and Ring functions. VWP is deployed into puncture in a porcine thoracic aorta and activated by warm saline flush to trigger shape recovery. Body and Ring mechanically seal the puncture, while the curved Wing promotes hemostatic sealing and subsequently flattens to maintain physiological blood flow. VWP achieves suturing-level hemostasis with preserved patency and endothelialization. Thrombo-hemodynamic balance is analyzed by computational modeling and validated using whole-blood microfluidic chip, demonstrating a material- and design-driven strategy for large-puncture vascular closure.