The Polymer Society of Korea

Abstract

In this study, we developed hybrid thermogels composed of octanoyl glycol chitosan (OGC) and gallic acid (GA) as multifunctional materials for hemostatic wound care. OGC is designed as a thermosensitive polymer that undergoes sol−gel transition near physiological temperature, and GA was incorporated at varying concentrations to form a series of OGC/GA thermogels. GA incorporation induced concentration-dependent modulation of the gels’ physical and mechanical properties, while imparting self-healing capability, enhanced tissue adhesion, and tunable degradation behavior. In addition, GA incorporation improved antioxidant and antibacterial performance, suggesting potential benefits for protecting the wound site and supporting a favorable healing environment. Overall, OGC/GA hybrid thermogels represent a promising multifunctional biomaterial platform for bleeding control and wound management.