[2PS-118]
A Multifunctional Hydrogel Platform Enabling ROS-Mediated Photodynamic Cancer Therapy
발표자권주영 (한양대학교)
연구책임자정현도 (한양대학교)
Abstract
Cancer therapy is often limited by poor selectivity and severe side effects, highlighting the need for localized and controllable platforms. In this study, we engineered a three-dimensional hydrogel system as a light-responsive biomaterial for photodynamic therapy. A biocompatible, photo-crosslinkable polymer network served as the structural matrix to support reproducible fabrication and cell compatibility. Inorganic nanoscale additives were introduced to tune mechanical performance, while a light-activated sensitizing molecule was embedded to generate reactive oxygen species under irradiation. Adipose tissue–derived stem cells were included as a biological component responsive to oxidative microenvironments. Physicochemical properties were assessed by mechanical testing, rheological analysis, swelling measurements, and microstructural/elemental observation to identify cell-suitable formulations for light-mediated therapy, with minimal invasiveness.