[3PS-089]
Coated Microneedle Array Patches Enabling Thermostable Malaria Vaccination
발표자성금용 (부산대학교)
연구책임자양승윤 (부산대학교)
Abstract
Transmission blocking vaccines (TBVs) target the sexual stage of the malaria parasite, and block mosquito-borne transmission. Pre-studied TBVs are administered intramuscularly as adjuvanted injectable formulations, which cause discomfort to patients and require cold storage. Transdermal microneedle (MN) vaccination offers a minimally invasive, potentially self-administered, skin delivery method that can induce immunity without adjuvants. However, precise dose control and ensuring antigen stability during manufacturing remain challenges. Here we developed TBV-coated MN patches using a low-temperature, nanoliter-scale, multiple contact-dispensing process and selectively coated Pfs230 or Pfs230-conjugate antigens on MN tips. In vivo MN vaccination elicited immune responses comparable to intramuscular injection. Unadjuvanted Pfs230 and Pfs230 conjugate MNs achieved titers similar to adjuvanted formulations and retained immunogenicity after 37°C storage.