The Polymer Society of Korea

마가은 (건국대학교)

박주호 (건국대학교)

Peptide therapeutics represent an important class of biomacromolecular drugs, yet their clinical application remains limited by poor oral bioavailability. Here, we report a supramolecular biohybrid nanocomplex for oral delivery of the peptide drug semaglutide, where the peptide itself functions as a polymeric therapeutic component. A positively charged bile acid–peptide conjugate forms a reversible non-covalent assembly with semaglutide, enabling transporter-mediated endocytosis via ASBT while preserving peptide integrity under gastrointestinal conditions. This study highlights how biomacromolecular peptides can be engineered through supramolecular interactions, offering a bio-convergent strategy that connects peptide-based polymers with next-generation drug delivery technologies.