High-Throughput Microphysiological Systems Through Material Transition
발표자
고지훈 (가천대학교)
연구책임자
고지훈 (가천대학교)
공동저자
고지훈 (가천대학교)
초록
내용
Microphysiological systems (MPS) have emerged as powerful in vitro platforms for modeling human physiology, yet their widespread adoption in drug screening has been limited by material-dependent constraints on scalability and throughput. In this presentation, we discuss the material transition of microfluidic MPS from polydimethylsiloxane (PDMS) to resin and ultimately to polystyrene-based platforms, and how this evolution impacts device throughput, assay robustness, and screening compatibility. By benchmarking chips with identical microarchitectures across different materials, we demonstrate that material-specific properties, including small-molecule absorption, surface stability, and fabrication reproducibility, critically influence drug response measurements. The transition toward thermoplastic platforms enables higher throughput, improved standardization, and seamless integration with conventional screening workflows. These results highlight practical design considerations for developing scalable MPS suitable for reliable drug screening applications.