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제출 정보

발표분야
대학원생 구두발표(발표15분)
발표 구분
구두발표
제목
Catechol-Coordinated Formable Bone Filler for Durable and Targeted Bone Regeneration
발표자

김영 (서울대학교)

연구책임자

정지홍 (서울대학교병원)

공동저자
김영 (서울대학교), 정수빈 (서울대학교), 최서윤 (서울대학교), 정지홍 (서울대학교병원)

초록

내용
The clinical need for bone grafts that conform to irregular defects like alveolar clefts is rapidly increasing. We developed a moldable bone-regenerating putty (HAp-E-COD₂E) by combining hydroxyapatite (HAp) with a polyelectrolyte coacervate system, COD₂E, composed of dopamine-functionalized fucoidan and poly-L-lysine. Catechol groups enabled strong metal–coordination bonding with hydroxyapatite (HAp), enhancing formability and structural integrity. COD₂E also functioned as a delivery platform for bone-regenerating exosomes (E-COD₂E), preserving their membrane integrity and enabling sustained release. This improved cellular uptake and reduced the need for repeated administration, addressing key limitations of conventional exosome therapies. By integrating controlled release, material adaptability, and osteoconductive coating, this coacervate-based system offers a promising strategy for effective bone tissue regeneration.
발표코드
O12-24
발표일정
2026-04-08  14:45 - 15:00