Coacervate Nanoassemblies via Amphiphilic Ligand Engineering for Biomedical Membrane Modulation
발표자
이재은 (울산과학기술원)
연구책임자
유자형 (울산과학기술원)
공동저자
이재은 (울산과학기술원), 유자형 (울산과학기술원)
초록
내용
Biomedical materials that directly modulate cell membrane integrity offer an alternative to intracellular signaling-based therapies. Here, we report amphiphilic ligand-engineered protein-nanoparticle nanoassemblies formed via electrostatic and hydrophobic interactions. Although the surface ligand are small molecules, their multivalent presentation generates a soft interfacial environment reminiscent of polymeric amphiphiles. Complexation with low pI proteins induces coacervate-like assemblies with tunable colloidal stability and membrane affinity. The catalase-nanoparticle exhibited strong membrane affinity while retaining enzymatic activity, enabling simultaneous membrane disruption and ROS modulation. This study demonstrates that interfacial design principles such as multivalency, amphiphilicity, and dynamic assembly enable nanoassemblies that couple mechanical membrane stress with catalytic microenvironment regulation