The Polymer Society of Korea

의료용 고분자 부문위원회

포스터발표

Hyaluronic Acid–Calcium Phosphate Nanoparticles for Enhanced Gene Delivery in hMSCs

이지현 (성균관대학교)

정지훈 (성균관대학교)

이지현 (성균관대학교), 김다훤 (성균관대학교), 여사연 (성균관대학교), 김병덕 (성균관대학교), 유빈 (성균관대학교), 정지훈 (성균관대학교)

Human mesenchymal stem cells (hMSCs) hold great potential for regenerative medicine, yet their variable in vivo behavior limits clinical translation. This study presents biocompatible calcium phosphate (CaP) nanoparticles stabilized with catechol-modified hyaluronic acid (dopa-HA) as a gene delivery platform to enhance hMSC osteogenic differentiation.

By leveraging the specific HA-CD44 receptor interaction, dopa-HA/CaP nanoparticles significantly improve transfection efficiency compared to branched polyethyleneimine (bPEI, 25 kDa) without cytotoxicity. Furthermore, co-delivery of BMP-2 pDNA and miRNA-148b through this system increases BMP-2 expression while downregulating Noggin, a natural inhibitor of BMP-driven osteogenesis. This dual-action strategy effectively bypasses biological bottlenecks, providing a robust and safe methodology for advanced bone tissue engineering.

3PS-114

2026-04-10  08:30 - 10:00