Repurposing the Use of Organic Cofactor: Synthesis and Characterization of Metalloflavins
발표자
임하늘 (한국과학기술원)
연구책임자
백윤정 (한국과학기술원)
공동저자
임하늘 (한국과학기술원), 백윤정 (한국과학기술원)
초록
내용
Inspired by nature’s use of flavins in electron transfer processes, we developed a flavin-based ligand (L) designed to facilitate hydrogen-bonding interactions in transition metal coordination. Coordination with first-row transition metals, ranging from Mn to Zn, regioselectively formed stable octahedral 2:1 ligand-to-metal complexes, where two chloride ions engaged in hydrogen-bonding. In the case of Fe, complexation with different halides led to variations in hydrogen-bonding interactions within the coordination sphere. Furthermore, ligand tautomerizationwas induced upon the addition of a base, leading to the formation of a water-coordinated Fe complex. This tautomerization event reorganized the hydrogen bonding network, allowing the nitrogen sites of the L to act as both hydrogen bond donors and acceptors. As a result, the L exhibited the ability to selectively capture external substrates through the switchable noncovalent interactions.