Molecular Design Strategy for Iridium(Ⅲ)-based Photosensitizers to Enhance the Phototoxicity Index and Efficacy of Photodynamic Therapy
발표자
윤광수 (울산과학기술원)
연구책임자
권태혁 (울산과학기술원)
공동저자
윤광수 (울산과학기술원), 박민규 (울산과학기술원), 권태혁 (울산과학기술원)
초록
내용
In photodynamic therapy (PDT), the phototoxicity index (PI) is crucial for evaluating photosensitizer (PS) efficiency, with dark toxicity lowering PI and increasing side effects. Ir(III)-based PSs effectively generate ROS, but some exhibit high dark toxicity, reducing PDT efficacy. Here, we propose a molecular design strategy to mitigate dark toxicity and enhance phototoxicity by modulating charge and incorporating organelle-targeting groups. Our results show that neutrally charged PSs exhibit lower dark toxicity than positively charged PSs, while organelle-targeting modifications enhance phototoxicity. This study highlights the importance of optimizing molecular charge and targeting properties to maximize PDT effectiveness.