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발표분야
의료용 고분자 부문위원회
발표 구분
포스터발표
제목
Development of a Vascularized Cardiac ECM-Based Hydrogel Platform for Myocardial Regeneration
발표자

김다인 (건양대학교)

연구책임자

이규배 (건양대학교)

공동저자
이규배 (건양대학교), 김다인 (건양대학교), 김규남 (건양대학교), 정현영 (건양대학교), 김지현 (건양대학교)

초록

내용
This study develops a biomimetic cardiac regeneration platform by integrating heart-specific decellularized extracellular matrix (dECM) with a microvascular network. To address myocardial infarction damage, cardiac dECM is optimized via physical and chemical processes to preserve essential bioactive components. Simultaneously, interconnected microchannels are fabricated within the hydrogel using pNIPAM as a thermo-responsive sacrificial fiber via centrifugal spinning. The platform's efficacy is evaluated through in vitro characterization, including mechanical strength analysis via compression testing and H&E staining for structural assessment. Biological validation focuses on cell viability (Live/Dead assay) and the expression of cardiomyocyte markers, such as $\alpha$-actinin and NKX2.5, to confirm functional maturation. This sophisticated in vitro model replicates the cardiac microenvironment, providing a robust tool for studying myocardial regeneration.
발표코드
1PS-046
발표일정
2026-04-09  09:00 - 10:30