Wound dressings are widely used to protect wounds and promote healing. The water absorption and antifriction properties of dressings are important for regulating the moisture balance and reducing secondary damages during dressing changes. Herein, we developed a hyaluronic acid (HA)–based foam dressing fabricated by lyophilizing photocrosslinked HA hydrogels, providing high absorbency and antiadhesive. Compared with conventional biopolymer foam dressings, the HA foam showed superior absorption and antifriction performance. In a rat model with full-thickness skin wounds (2 × 2 cm²), the HA foam promoted wound healing over 24 days without inducing inflammation and reduced secondary injury during dressing changes compared with gauze and commercial dressings. This research presents a promising biocompatible foam wound dressing based on modified HA, which offers enhanced wound-healing capabilities and improved patient comfort and addresses the challenges associated with conventional dressings.