Diabetic wounds feature excessive oxidative stress, impaired angiogenesis, chronic inflammation, and delayed cellular regeneration, which together impede healing. Persistent reactive oxygen species (ROS) disrupt homeostasis, damage tissue, and suppress angiogenic signaling, driving the need for therapies that control ROS while supporting repair. Graphene Oxide (GO) is a functional biomaterial with ROS-scavenging and photothermal properties; under near-infrared (NIR) irradiation it can generate mild hyperthermia that may enhance cellular activity, improve microcirculation, and provide antibacterial effects. Polydeoxyribonucleotide (PDRN), a DNA-derived polymer, promotes proliferation and angiogenesis via adenosine A2A receptor activation and may modulate inflammation and oxidative stress. Here, we investigate a GO–PDRN hydrogel platform that integrates these complementary functions to evaluate their combined potential for diabetic wound healing.