Electrically Responsive Drug Release Utilizing Charge-Tunable Collagen Hydrogels
발표자
장세윤 (한국과학기술연구원, 고려대학교 KU-KIST 융합대학원)
연구책임자
류진 (한국과학기술연구원)
공동저자
장세윤 (한국과학기술연구원, 고려대학교 KU-KIST 융합대학원), 류진 (한국과학기술연구원), 전호정 (한국과학기술연구원, 고려대학교 KU-KIST 융합대학원)
초록
내용
In hydrogel-based drug delivery systems, drug release is often governed by passive diffusion, which limits active control over release behavior. To address this limitation, we developed a collagen-based hydrogel as a charge-controlled polymer platform enabling electrically responsive drug release. The collagen network was stabilized through coordination bonding with Pt metal ions, providing robustness under electrical stimulation. Owing to its polyampholytic nature, collagen enables regulation of network charge density via electrostatic interactions with poly(ethyleneimine), unlike neutral polymers such as poly(ethlene glycol). As a result, the hydrogel suppressed nonspecific drug leakage while enhancing drug loading and electrically induced release of charged drugs. This charge-controlled polymer platform demonstrates a versatile polymer design strategy for electrically responsive systems with utility in iontophoresis-related drug delivery and bioelectronic interface applications.