DNA-Mediated force transmission for precise and efficient mechanophore activation
발표자
구민정 (국립부경대)
연구책임자
곽민석 (부경대학교)
공동저자
구민정 (국립부경대), 곽민석 (부경대학교), 김규린 (광주과학기술원), Banyu Firdaus Soeriawidjaja (부경대학교)
초록
내용
Mechanophores (MPs) are typically embedded in synthetic polymers to enable force-mediated chemical transformations. In contrast to traditional systems that require hours of sonication, DNA-based systems enable reactions to complete in minutes and are compatible with high-throughput analysis using gel electrophoresis. By designing DNA-mechanophore-DNA architectures with tunable lengths (100 to 1000 base pairs) and different synthetic mechanophores, we achieve nearly complete mechanophore scission (99.9%) while using medical ultrasound. DNA sequencing and mass spectrometry confirm selective bond cleavage in DNA architectures. This DNA-based system offers a time- and cost-efficient platform for mechanophore development providing a versatile approach to carrying out mechanochemistry research in general.