ChS-APBA/EGCG Functionalized PHB/PEO Ultrafine Fiber Sheets for Enhanced Tissue Adhesion and Wound Healing
발표자
김유정 (금오공과대학교)
연구책임자
권오형 (금오공과대학교)
공동저자
권오형 (금오공과대학교), 김유정 (금오공과대학교)
초록
내용
Wounds may develop into chronic conditions due to severe tissue damage or diseases such as diabetes, causing serious physical and psychological burden. In this study, polyhydroxybutyrate (PHB)/poly(ethylene oxide) (PEO) (8:2) ultrafine fiber sheets were fabricated and functionalized with chondroitin sulfate (ChS), (3-aminomethyl phenyl) boronic acid (APBA), and epigallocatechin-3-gallate (EGCG) for wound healing applications. PHB is a promising biomaterial due to its elasticity, biodegradability, and biocompatibility, while PEO was introduced to improve spinnability. ChS-APBA/EGCG coating enhanced tissue adhesion and fibroblast growth through dynamic covalent bonding and stabilized EGCG. The coated sheets exhibited soft, elastic, and extracellular matrix-like structures, supporting cell proliferation and migration. In vivo studies demonstrated superior wound healing performance compared to conventional dressings, indicating strong potential as advanced wound dressing materials.