Poly(β-amino ester)–based polymeric nanoparticles for mRNA delivery
발표자
장민환 (포항공과대학교)
연구책임자
김원종 (포항공과대학교)
공동저자
장민환 (포항공과대학교), 김원종 (포항공과대학교)
초록
내용
Messenger RNA (mRNA) therapeutics now extend beyond COVID-19 vaccines to protein replacement and immune modulation, but delivery is a central bottleneck because mRNA is unstable and must reach the cytosol. Lipid nanoparticles (LNPs) transfect efficiently, yet off-target distribution, innate immune activation, and organ toxicity drive interest in alternatives. Polymeric nanoparticles (PNPs), especially poly(β-amino ester) (PBAE) systems, offer biocompatibility, lower innate immunogenicity, and design flexibility. PBAEs allow systematic tuning via monomer choice and formulation to match specific applications. Recent work shows optimized PBAE nanoparticles can yield localized, prolonged mRNA expression after intramuscular injection while limiting systemic exposure and reducing liver-associated toxicity. Ongoing optimization positions PBAE-based PNPs as potentially safer, versatile carriers that broaden mRNA applications beyond current vaccine platforms.