Liposome-Encapsulated Ferroptosis Inducers for Overcoming Cancer Metastasis and Drug Resistance
발표자
류수현 (서울대학교)
연구책임자
이강원 (서울대학교)
공동저자
류수현 (서울대학교), 배채원 (서울대학교), 이강원 (서울대학교)
초록
내용
Cancer metastasis and drug resistance are driven by metabolic reprogramming and extracellular matrix remodeling that also limit ferroptosis sensitivity. Here, we develop a liposomal nanoplatform coencapsulating iron oxide nanoparticles, lactate oxidase, and the lysyl oxidase inhibitor PAT-1251 to induce ferroptosis while suppressing metastasis-associated pathways. This system simultaneously promotes iron-dependent lipid peroxidation, depletes lactate, and inhibits LOX-mediated ECM remodeling. As a result, the platform enhances ferroptotic cell death, improves drug penetration, and reduces metastatic potential. In vitro and in vivo studies demonstrate effective tumor suppression and mitigation of drug resistance compared with single-component treatments. This work highlights a metabolism- and microenvironment-targeted ferroptosis strategy for advanced cancer therapy.