A Design Map for PEG Nanogels: From Molecular Choices to Bulk Rheology
발표자
천서윤 (서울대학교)
연구책임자
김정욱 (서울대학교)
공동저자
천서윤 (서울대학교), 김정욱 (서울대학교)
초록
내용
Soft nanogels promise injectable, biocompatible formulations with tunable flow and solid-like stability, but their bulk rheology remains largely recipe-driven because particle volume, interactions, and mechanics evolve under crowding. Here we establish a molecular-to-bulk “design map” for PEG-based nanogels: how molecular choices (PEGDA molar mass, crosslink architecture, ionic content, and polymerization conditions) translate into particle-scale properties (swelling/compressibility, core–corona structure, effective interactions) and ultimately into macroscopic viscoelasticity, yielding, and flow. By combining controlled synthesis with quantitative characterization across dilute to crowded states, we provide predictive rules to engineer targeted rheological windows relevant to injectable depots, thickeners, and soft-solid processing.