Indocyanine Green J-aggregate Nanosuspension with High Loading Efficiency for Photothermal Therapy
발표자
김예리 (서울대학교)
연구책임자
안철희 (서울대학교)
공동저자
김예리 (서울대학교), 안철희 (서울대학교)
초록
내용
Indocyanine green (ICG) has been widely investigated for applications in photothermal therapy (PTT). J-aggregated ICG (J-ICG) has been employed to enhance molecular stability and quantum efficiency. However, J-ICG are prone to dissociation in solution when combined with other materials during particle formation. In this study, a PLL@J-ICG nanosuspension was successfully prepared by wet media milling of J-ICG with Poly-L-lysine (PLL) in methanol, enabling the preservation of the J-aggregate structure through electrostatic interactions between PLL and J-ICG. The resulting nanoparticles exhibited an average particle size of 319.7±101.0 nm, and the milling-based approach achieved higher loading amount compared to conventional bottom-up methods. in vitro photothermal conversion studies demonstrated that PLL@J-ICG exhibited photothermal conversion efficiency comparable to that of free J-ICG, indicating its strong potential as a therapeutic and imaging agent for PTT applications.