Lipid Biomaterial-Based Macrophage Surface Engineering for Autoimmune Disease Treatment via B cell Targeting Enhancement
발표자
박민경 (동국대학교)
연구책임자
김교범 (동국대학교)
공동저자
박민경 (동국대학교), 김은하 (동국대학교), 김교범 (동국대학교)
초록
내용
Macrophages are pivotal cells of the innate immune system that directly suppress pathogenic cells via phagocytosis. Autoimmune diseases occur from abnormal immune responses to self-antigens, causing inflammation and tissue damage. Accordingly, B cells contribute by producing autoantibodies that amplify inflammatory cascades. Here, we suggest a lipid-biomaterial platform to enhance macrophage-mediated elimination of pathogenic B cells. The biomaterial employs a lipid domain that stably anchors to the macrophage membrane and a hyaluronic acid as a targeting moiety that binds to CD44 which is highly expressed on activated B cells. As an intercellular bridge, it reduces physical distance and promotes synaptic engagement, thereby improving recognition so that macrophages can deplete overactivated B cells via phagocytosis. This precise modulation of cell-to-cell interactions may enable primitive immunological reprogramming that is difficult to achieve with conventional chemical drugs.