GelMA-Based Electroconductive Hydrogel Nanocomposite for Accelerating Bone Regeneration
발표자
류경민 (한양대학교)
연구책임자
정현도 (한양대학교)
공동저자
류경민 (한양대학교), 강형석 (한양대학교), 정현도 (한양대학교)
초록
내용
Electrostimulation therapy (EST) has been investigated to promote bone regeneration, but current electrostimulation materials face challenges, including limited biocompatibility and unsuitable properties. This study aimed to improve an electroconductive hydrogel composed of gelatin methacryloyl (GelMA), MXene, and DNA. GelMA provides biocompatibility and tunable mechanical properties for bone regeneration. MXene developed electroconductivity and mechanical strength, but may induce oxidative stress and cytotoxicity. To address this, MXene was coated with polydopamine (PDA) and DNA to improve biocompatibility and regenerative potential. FT-IR, XPS, and DLS confirmed surface modification. The composite hydrogel showed enhanced mechanical and electrical properties. In Vitro results demonstrated reduced cytotoxicity in PDA-MXene and increased cell proliferation under EST. These findings suggest the composite hydrogel is a promising platform for bone tissue engineering by EST.