Rapid Fabrication of Multi-layer Microneedles via a Reaction–Diffusion Process Using Photocurable Materials
발표자
손은지 (아주대학교)
연구책임자
심태섭 (아주대학교)
공동저자
손은지 (아주대학교), 심태섭 (아주대학교)
초록
내용
Conventional hypodermic injections often cause pain and anxiety, making them unsuitable for self-administration. Microneedle-based transdermal delivery has emerged as a minimally invasive and patient-friendly alternative. However, the commonly used micromolding method requires long processing times and may compromise drug stability due to repeated centrifugation. Here, we propose a reaction–diffusion-based fabrication strategy using photocurable materials for rapid production of multi-layer microneedles. By controlling the competition between UV-induced polymerization and oxygen diffusion, microneedles can be fabricated in a short time. Also, multi-layer architectures can be achieved through sequential processing. Mechanical and cytotoxicity evaluations confirmed their robustness and biocompatibility, demonstrating potential for reliable transdermal drug delivery.