Hydrogels are widely studied as wound dressings due to their excellent biocompatibility and moisture retention, but their clinical application is limited by poor mechanical strength and functionality. To address this issue, a methacrylate-modified hyaluronic acid (HAMA) hydrogel was developed to enhance mechanical properties while maintaining biocompatibility. MXene nanosheets and salmon-derived DNA were incorporated to provide multifunctionality. MXenes enabled photothermal therapy through localized heating, promoting angiogenesis and accelerating wound closure, while salmon-derived DNA supplied bioactive cues for tissue regeneration. The hydrogel was characterized by NMR and FT-IR analyses. In vitro and in vivo studies demonstrated improved wound healing performance. These results indicate that the multifunctional HAMA-based hydrogel is a promising advanced wound dressing with enhanced mechanical and biological properties.