Redox-Triggered and Antifouling Hyperbranched Polyglycerol–Organosilica Nanoparticles for Selective Cancer Therapy
발표자
양경석 (울산과학기술원)
연구책임자
유자형 (울산과학기술원)
공동저자
양경석 (울산과학기술원), 유자형 (울산과학기술원)
초록
내용
Nanoparticles in physiological fluids rapidly form protein corona, causing nonspecific adsorption, opsonization, and macrophage clearance. PEGylation reduces but cannot eliminate protein binding or immune recognition. Herein we developed hyperbranched polyglycerol-coated mesoporous organosilica nanoparticles (HPG-MONs) as stealth, GSH-responsive nanocarriers for cancer therapy. Dense HPG hydration profoundly suppressed protein adsorption and macrophagic internalization, validated by quantitative proteomics and confocal studies. HPG-MONs displayed excellent colloidal stability, high hydrophobic drug loading, and reductive degradation. In tumor-bearing mice, dye-loaded-HPG-MONs showed superior tumoral accumulation with reduced off-target sequestration versus unmodified/PEGylated controls. These properties establish HPG-MONs as advanced platforms combining antifouling, stimuli-responsive degradation, and optimized biodistribution for precision cancer treatment.