Tailored Surface Engineering of NK Cells with CD44‐Targeting Lipid Biomaterials for Augmented Cancer Immunotherapy
발표자
김성준 (국립암센터)
연구책임자
김성준 (국립암센터)
공동저자
김성준 (국립암센터)
초록
내용
Adoptive immunotherapy using natural killer (NK) cells remains limited in solid tumors due to insufficient expression of tumor-targeting ligands. To overcome this, a modular polymer “Hyaluronic acid (HA)-PEG-Lipid” was developed for cell surface engineering. The polymer structure was optimized to anchor on NK membranes, producing CD44-targeting HA-presenting NK (HANK) cells with enhanced immune synapse formation and cytotoxicity against CD44-positive pancreatic cancer cells. In mouse models, HANK cells improved tumor infiltration and suppressed tumor growth and metastasis. Glucose and boronic acid were conjugated to the polymer to enable dual targeting of GLUT1 and sialic acid, and the resulting system was successfully applied for glioblastoma and colorectal cancer treatments. This study presents a tunable surface engineering platform for immune cell functionalization and a strategy to enhance NK cell–mediated immunotherapy across diverse solid tumors.