Systemically Linked Propulsion of Enzymatically Powered Nanobots for Treatment of Inflammatory Intestinal Disorders
발표자
서예원 (포항공과대학교)
연구책임자
한세광 (포항공과대학교)
공동저자
서예원 (포항공과대학교), 최현식 (한림대학교), 한세광 (포항공과대학교)
초록
내용
Collective motion in living organisms has inspired artificial swarming systems for biomedical applications. Enzyme-driven micro/nanobots are attractive due to their ability to autonomously generate chemical signals, yet interactions between distinct swarms remain largely unexplored. Here, we present a dual-swarm enzymatic nanobot platform enabling chemical communication between glucose oxidase– and catalase-based nanobots for the treatment of inflammatory intestinal disorders. Their collective behavior was investigated in microfluidic environments and evaluated in vivo via intrarectal administration in a murine model of intestinal inflammation. The nanobot swarms migrated along the colonic lumen, showed prolonged retention at inflamed sites, and significantly restored tissue integrity with reduced proinflammatory cytokine expression. These results demonstrate the therapeutic potential of chemically communicating nanobot swarms for inflammatory intestinal diseases.