의료용 고분자 부문위원회 II: 바이오 고분자 혁신: 차세대 융합소재와 응용 (2)
[2L1-9]
Patient-Specific Brain Organoids for Precision Neurotherapeutics
발표자박종찬 (Sungkyunkwan University)
연구책임자박종찬 (Sungkyunkwan University)
Abstract
iPSC-derived brain organoids offer a promising platform for modeling neurodegenerative diseases and evaluating drug responses in a patient-specific context. Our research involves CRISPR-Cas9 editing of genes such as ApoE and TREM2, as well as the use of patient-derived iPSCs carrying disease-associated mutations. These models support high-content imaging-based drug screening and tissue-clearing techniques for functional assessment. While rooted in neuroscience, this work has potential to benefit from integration with biomedical materials—such as biofunctional scaffolds or delivery systems. This talk aims to share our organoid-based precision medicine approach and explore future synergy with advanced medical materials.