[2PS-057]
Dual-drug loading β-cyclodextrin pocket surfactants for enhanced pharmaceutical delivery
발표자임은정 (성균관대학교)
연구책임자김진웅 (성균관대학교)
Abstract
β-Cyclodextrin (β-CD) possesses a toroidal hydrophobic cavity that favors hydrophobic drug inclusion complexation. We rationally designed amphiphilic β-CD derivatives as "pocket surfactants" exploiting dual encapsulation mechanisms: molecular inclusion within the native cavity and supramolecular assembly through micelle formation. Schiff base conjugation introduces alkyl chains with predetermined lengths, modulating hydrophilic-lipophilic balance. This structural modification dictates self-assembly thermodynamics, yielding alkyl chain length-dependent critical micelle concentrations and micelle size distributions. UV–vis spectroscopy enables quantitative drug loading stoichiometry determination, while in vitro dissolution studies reveal sustained release profiles governed by diffusion and desorption mechanisms. The convergence of molecular recognition and colloidal self-assembly establishes our pocket surfactants as versatile nanocarrier platforms for dual-drug delivery applications.