[2PS-070]
Biocompatible and Biodegradable L-Lysine Polyurethane (LPU) Nanoparticles for Drug Delivery Applications
발표자최지운 (부산대학교)
연구책임자정일두 (부산대학교)
Abstract
To obtain biodegradable biomaterial for matrix of drug delivery, L-lysine polyurethane (LPU) was designed using PLA-PEG-PLA triblock oligomer as a soft segment, 1,6-hexamethylene diisocyanate (HMDI) as a hard segment and L-lysine ethyl ester (LEE) as a chain extender. PLA-PEG-PLA was synthesized by ring opening polymerization (ROP) of lactide monomer onto poly(ethylene glycol) core and stannous octoate as a catalyst. LEE was synthesized by esterification of L-lysine with ethanol using thionyl chloride as a catalyst. LPU nanoparticles were fabricated by using water-in-oil-in-water double emulsion technique for encapsulating anticancer drugs such as 5-fluorouracil (5-FU). The structure and composition were confirmed by 1H-NMR, 13C-NMR, and FT-IR; molecular weights measured by GPC; nanoparticle morphology analyzed via DLS, FE-SEM, and TEM; drug encapsulation visualized by confocal microscopy; loading efficiencies evaluated by UV/Vis spectroscopy.