[2PS-071]
Synthesis and Characterization of Crosslinked Hyaluronic Acid Using Polymerizable Polyrotaxane
발표자최지운 (부산대학교)
연구책임자정일두 (부산대학교)
Abstract
Hyaluronic acid (HA) has attracted considerable attention as a wound healing material due to its excellent biocompatibility and moisturizing properties. However, its application is often limited by insufficient mechanical strength and rapid degradation in vivo. To address these issues, we developed a HA-based hydrogel utilizing polymerizable polyrotaxane (PRMA) as a multifunctional crosslinker. Polyrotaxane was synthesized by threading β-cyclodextrin onto poly(propylene glycol) (PPG, MW = 4000), followed by end-capping with N-(triphenylmethyl)-glycine (Trt-Gly-OH) using DMT-MM as a catalyst. Methacryloyl chloride was subsequently grafted onto the threaded β-cyclodextrin to introduce polymerizable groups. Characterization by NMR, FT-IR, DSC and TGA confirmed the chemical structure and properties of the synthesized materials.