[3PS-227]
Development of Shape Memory Polymer-based Microneedle Patch for Interstitial Fluid Extraction
발표자김현재 (연세대학교 )
연구책임자성학준 (연세대학교), 이강석 (티엠디랩)
Abstract
Recently, interstitial fluid (ISF) has attracted attention in healthcare, medical and biomedical applications because it exists in the extracellular space and diffuses in the blood vessels, and ISF has a composition like that of blood. Due to various biomarkers in ISF, if we can extract ISF and use of them such as a biosensor to provide bio-information, we can provide useful health information to both clinicians and patients.
For effective ISF extraction, we developed a microneedle structure and used shape memory microneedle technology (INNOSELF-MN). We first designed a novel microneedle design including a hollow type of microneedle structure and a filled microneedle structure. Then, we set up a manufacturing process for microneedles with two shapes such as cone shape and x-shape using shape memory programming process and established a protocol for fluid extraction. Based on this study, we developed a shape memory microneedle capable of ISF extraction.