[2PS-067]
Synthesis and characterization of l-tyrosine polyester(LPE) for biocompatible drug delivery vehicle
발표자한서영 (부산대학교)
연구책임자정일두 (부산대학교)
Abstract
L-Tyrosine, a naturally occurring amino acid containing both amino and carboxylic functional groups, is a promising candidate for biomedical materials due to its high biocompatibility and functionality. In this study, a novel L-tyrosine-based polyester (LPE) was synthesized to serve as a biodegradable carrier for therapeutic agents. The polyester backbone was constructed via esterification between desaminotyrosyl tyrosine hexyl ester (DTH), as a diol which was pre-synthesized from L-tyrosine and 1-hexanol, and succinic acid, as a biocompatible dicarboxylic acid. All the synthetic processes were confirmed by ¹H-NMR, ¹³C-NMR and FT-IR spectroscopies, and the molecular weight of the polyester was characterized by GPC. In the future, we plan to use water-in-oil-in-water double emulsion technology to fabricate nanoparticles having drugs or genes.