The Polymer Society of Korea

차경엽 (동국대학교)

이수홍 (동국대학교)

Nanotechnology shows strong potential in regenerative medicine, especially for tissue repair and targeted delivery. Mesenchymal stem cell-derived nanovesicles (MSC-CNVs) are biocompatible and bioactive but limited by low yield and poor targeting. To address this, we developed a hybrid system combining tauroursodeoxycholic acid (TUDCA) to enhance CNV production with bisphosphonate-conjugated lipid nanoparticles (BP-LNPs) for bone targeting. TUDCA-functionalized CNVs (TCNVs) improved yield and regenerative factor levels. BP-hybridized CNVs (BP-hCNVs) enhanced cell uptake and reduced clearance. Ex vivo imaging showed superior bone accumulation. BP-hTCNVs promoted osteogenic differentiation and significantly improved bone regeneration in an ovariectomy-induced osteoporosis mouse model. This hybrid system offers a promising nanoplatform with enhanced efficiency, targeting, and osteoregenerative function for osteoporosis therapy.