Rationally Designed Self-Immolative Polymeric Prodrug Nanoparticles for Therapeutic and Bioimaging Applications
발표자
이동원 (전북대학교)
연구책임자
이동원 (전북대학교)
초록
내용
Recent advance in nanotechnology, biology and chemistry have led to the development of various stimulus-responsive polymeric nanomaterials for biomedical applications such as drug delivery and bioimaging. When polymers are designed to respond specifically the pathological conditions, their medical performance could be further enhanced, enabling precise nanomedicines. Compared to normal cells and tissues, pathological conditions such as cancer and inflammation have altered redox balance and acidic pH. In our lab, we developed several polymers for therapeutic and imaging applications by exploiting simple chemistry to respond altered redox balance and acidic pH in various pathological conditions. I will discuss molecularly engineered biopolymer nanoparticles implicating that simple chemistry extends the medical applications of polymeric nanoparticles.